Origin and evolution of STAT, WNT and the nuclear receptor superfamily, NR

○S. Abe, E. Sasaki, T. Kishida, K. Ebihara (Fac. Agriculture, Ehime Univ.)


Phylogeny of NR for lipid metabolism (RXR, RAR, PPAR), steroid hormone reception (GR, MR, ESR, AR), and other (THR, VDR, TR2, TR4), and WNT members were studied in lower and higher vertebrates. Analysis of their genomic organization showed considerable conservation of exon organiza- tion and a nearly universal exon linkage in NR was found. An RXR and NR2F1 were identified inCiona intestinalis with similar genomic structures, and NR2F1 at 5q14 shared the same structure with human PPARG at 3p25, indicating the NR2F1 is the direct source of NR and NR2F1 was already created from RXR before evolution of Ciona. Ten WNTs in Ciona shared similar genomic structure to vertebrates, and analyses of flanking genes demonstrated evolutionary linkages of NR, WNT, and STAT to the human 3p14-26 and also to 1q21-42, 2q11-35, 5q12-35, 6p21-25, 12q11-13, 17q11-21 and 22q11-13 syntenies. Homodimer or heterodimer formation and their functional overlap might play a key role in the coordinated evolution and differentiation of NR , WNT, and STAT members.


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