Toxicity of Goitrigens, which are contained in most of Brassica family and some other food such as soybean.   For more reports, click here   food safety issue

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TITLE: Studies on a long-term use of rapeseed products in diets for boars. Pathomorphological changes in the reproductive system, liver and thyroid gland.
AUTHORS: Rotkiewicz T; Bomba G; Falkowski J; Glogowski J; Kozera W; Kozlowski M
AUTHOR AFFILIATION: Department of Pathological Anatomy, Faculty of Veterinary Medicine, University of Agriculture and Technology in Olsztyn, Poland. Toidrot@moskit.ART.Olsztyn.PL
SOURCE: Reprod Nutr Dev 1997 Nov-Dec;37(6):675-90
CITATION IDS: PMID: 9477436 UI: 98137923
ABSTRACT: Three feeding groups were used: the control (SOY) was fed diets without rapeseed products, and the two experimental groups were fed with either 10% rapeseed meal (RSM) or with 12% OO rape seeds (PFRS). Half of the boars from each group were slaughtered after 1 or 2 years. In RSM and PFRS boars steroid-3-beta-ol-dehydrogenase activity was high, whilst Leydig cells were not numerous after 1 year. Degeneration and necrosis of seminiferous epithelium resulting in atrophy of seminiferous tubules appeared in RSM boars after 2 years. In the PFRS group the lesions were stronger and proliferation of Leydig cells with high steroid-3-beta-ol- dehydrogenase activity was observed. In 1-year-old RSM and PFRS boars there were foci of necrosis in the epididymal epithelium. Thyroid weight in RSM boars and liver weight in PFRS boars were distinctly higher only during the first year. In these thyroid glands flattening of glandular epithelium and enlargement of colloid masses were observed, while in the livers, parenchymatic degeneration and structural transformation appeared. Testis weight increased after 2 years in RSM and PFRS boars; however, this had little effect on semen production.
MAIN MESH HEADINGS: *Animal Nutrition
Brassica/*adverse effects
Liver/*pathology
Swine/*physiology
Testis/*pathology
Thyroid Gland/*pathology
ADDITIONAL MESH HEADINGS: Animal
Cohort Studies
Comparative Study
Diet/methods
Female
Liver/physiology
Male
Organ Weight/physiology
Semen/cytology
Semen/physiology
Testis/physiology
1998/02
1998/27 03:02
PUBLICATION TYPES: JOURNAL ARTICLE
LANGUAGES: Eng

2

TITLE: Alkaline heating of canola and rapeseed meals reduces toxicity for chicks.
AUTHORS: Barrett JE; Klopfenstein CF; Leipold HW
AUTHOR AFFILIATION: Department of Biology, Kansas State University, Manhattan, USA.
SOURCE: Plant Foods Hum Nutr 1998;52(1):9-15
CITATION IDS: PMID: 9839830 UI: 99053565
ABSTRACT: A simple method for improving the nutritive quality of canola and high glucosinolate rapeseed meals for monogastric animals (chicks) was developed; the meals were mixed with NaHCO3 and NH4HCO3, then heated in a conventional oven. Chicks fed untreated canola or rapeseed meals gained less weight than those fed a soybean meal diet, whereas chicks fed the alkaline-heated meals had weight gains not significantly different than those fed the soybean diet. The antithyroid effect of the untreated rapeseed meal was reduced by alkaline treatment of the meals, as shown by improved T4 and free T4 levels in chicks fed the processed products. In chicks fed untreated or alkaline-treated canola or alkaline heated rapeseed meal, all thyroid hormone levels were similar to those of birds fed the soybean meal diet. However, heart tissue of chicks fed diets containing rapeseed or canola meals showed muscle fiber degeneration, although relative heart weights were the same in all groups. Liver tissue from most of the chicks in all dietary groups appeared normal or only slightly abnormal. The nutritive value of both rapeseed and canola meals was improved by this simple processing technique.
MAIN MESH HEADINGS: *Animal Feed
*Brassica
*Plants, Edible
ADDITIONAL MESH HEADINGS: Animal
Body Weight
Brassica/chemistry
Chickens
Food Handling
Glucosinolates/chemistry
Heating
Hydrogen-Ion Concentration
Myocardium/pathology
Nutritive Value
Organ Weight
Salts
Thyroid Hormones/metabolism
1998/12
1998/05 03:44
PUBLICATION TYPES: JOURNAL ARTICLE
CAS REGISTRY NUMBERS: 0 (Glucosinolates)
0 (Salts)
0 (Thyroid Hormones)
LANGUAGES: Eng

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TITLE: [The effect of thioglycoside-containing feed on the growth, thyroid hormone and thiocyanate status of swine and poultry]
VERNACULAR TITLE: Einfluss thioglycosidhaltigen Futters auf Wachstum, Schilddrusenhormon- und Thiocyanatstatus von Schwein und Geflugel.
AUTHORS: Schone F; Paetzelt H; Lange R; Jahreis G; Ludke H
AUTHOR AFFILIATION: Landwirtschaftliche Untersuchungs- und Forschungsanstalt Thuringen, Bereich Ernahrung und Markt, Jena.
SOURCE: Berl Munch Tierarztl Wochenschr 1994 Dec;107(12):418-21
CITATION IDS: PMID: 7717962 UI: 95234021
ABSTRACT: Feed containing rapeseed meal (RSM) with high glucosinolate content (10 mmol/kg feed) induced a strong increase of thyroid weight in pigs and poultry. Supplementary iodine reduced the antithyroid effect, but, it could not cancel it. Only at a low glucosinolate content (0.7 mmol/kg feed) a normal weight of thyroid was established. As the iodine supplementation increased the serum T4 value increased. The thiocyanate serum level increased irrespective of glucosinolate content of the feed. The urine level was significantly decreased due to lower dietary glucosinolate level. Obviously, the goitrogenic effect of the RSM does not correlate with the increased thiocyanate serum level.
MAIN MESH HEADINGS: Chickens/*growth & development
Glucosinolates/*pharmacology
Swine/*growth & development
Thiocyanates/*blood
Thyroid Hormones/*blood
ADDITIONAL MESH HEADINGS: Animal
Animal Feed
Brassica
Chickens/metabolism
English Abstract
Glucosinolates/administration & dosage
Male
Swine/metabolism
1994/12
1994/01 00:00
PUBLICATION TYPES: JOURNAL ARTICLE
CAS REGISTRY NUMBERS: 0 (Glucosinolates)
0 (Thiocyanates)
0 (Thyroid Hormones)
LANGUAGES: Ger

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